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Product Name
Cyclophilin A antibody
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Description
Cyclophilin A Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells. Observed molecular weight by Western-blot: 18kd
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Tested applications
ELISA, WB
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Species reactivity
Human, Mouse, Rat; other species not tested.
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Alternative names
Cyclophilin A antibody; Cyclosporin A binding protein antibody; CYPA antibody; CYPH antibody; PPIA antibody; PPIase A antibody; Rotamase A antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Cyclophilin A recombinant protein (Accession Number: NM_021130). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:109672(PPIA antibody) at dilution of 1:500
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Background
PPIA, also named as CYPA and Rotamase A, belongs to the cyclophilin-type PPIase family and PPIase A subfamily. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIA forms a trimolecular complex with cyclophilin and calcineurins to inhibit calcineurin phosphatase activity. PPIA is incorporated into the virion of the type 1 human immunodeficiency virus (HIV-1) via a direct interaction with the capsid domain of the viral Gag polyprotein and is crucial for efficient viral replication.
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