-
Product Name
Human CDK2AP2 (His Tag) recombinant protein
- Documents
-
Description
CDK2AP2 belongs to the CDK2AP family. Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. CDK2AP2 contains 5 distinct gt-ag introns. Transcription produces 7 different mRNAs, 6 alternatively spliced variants and 1 unspliced form. There are 2 non overlapping alternative last exons and 4 validated alternative polyadenylation sites. The mRNAs appear to differ splicing versus retention of 3 introns. CDK2AP2 plays a role in regulating self-renewal of mouse embryonic stem cells (mESC) under permissive conditions, and cell survival during differentiation of the mESC into terminally differentiated cell types.
-
Protein name
Cyclin-dependent kinase 2-associated protein 2
-
Protein short names
D19ERTD144E; DOC-1R; DOC-1 RELATED PROTEIN; 5830466O21RIK; TUMOR SUPPRESSOR DELETED IN ORAL CANCER RELATED 1; DOC-1-RELATED PROTEIN; CDK2-ASSOCIATED PROTEIN 2; P14; FLJ10636; CYCLIN-DEPENDENT KINASE 2-ASSOCIATED PROTEIN 2
-
Uniprot ID
O75956
-
Gene Name
CDK2AP2; DOC1R
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
A DNA sequence encoding the human CDK2AP2 (O75956) (Met 1-Thr 126) was fused with a polyhistidine tag at the C-terminus.
-
Protein Species
Human
-
Molecular weight
The recombinant human CDK2AP2 consists of 136 amino acids and has a calculated molecular mass of 14.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of human CDK2AP2 is approximately 18 and 12 kDa due to different glycosylation.
-
Purity
> 78 %(the upper band)+17 %(the lower band) as determined by SDS-PAGE
-
Validations
Human CDK2AP2 Protein (His Tag) SDS-PAGE
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"