Human CREB3L1 / OASIS (aa 396-519, His Tag) recombinant protein

Human CREB3L1 / OASIS (aa 396-519, His Tag) recombinant protein

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Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (PubMed:21767813). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed:21767813).

Cyclic AMP-responsive element-binding protein 3-like protein 1

CREB3L1; CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1; OLD ASTROCYTE SPECIFICALLY INDUCED SUBSTANCE; BBF-2 HOMOLOG; RP23-37B7.1; OASIS; PSEC0238; CYCLIC AMP-RESPONSIVE ELEMENT-BINDING PROTEIN 3-LIKE PROTEIN 1; CAMP RESPONSIVE ELEMENT BINDING PROTEIN 3-LIKE 1

Q96BA8

CREB3L1; OASIS; PSEC0238

Human Cells

A DNA sequence encoding the human CREB3L1 (Q96BA8-1) (Glu396-Ser519) was expressed with a polyhistidine tag at the C-terminus.

Human

The recombinant human CREB3L1 consists of 135 amino acids and predicts a molecular mass of 15.2 KDa. It migrates as an approximately 21-31 KDa band in SDS-PAGE under reducing conditions.

> 95 % as determined by SDS-PAGE