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CXCR7 antibody

Cat.#: 109645

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Product Information

  • Product Name
    CXCR7 antibody
  • Documents
  • Description
    CXCR7 Rabbit Polyclonal antibody. Positive FC detected in Raji cells. Positive WB detected in Raji cells, Jurkat cells, K-562 cells, mouse thymus tissue. Positive IP detected in HUVEC cells. Observed molecular weight by Western-blot: 45-50kd
  • Tested applications
    ELISA, WB, IP, FC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    Chemokine orphan receptor 1 antibody; CMKOR1 antibody; CXC R7 antibody; CXCR 7 antibody; CXCR7 antibody; G protein coupled receptor 159 antibody; GPR159 antibody; RDC 1 antibody; RDC1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of CXCR7 recombinant protein (Accession Number: XM_047445135). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IP: 1:200-1:2000

  • Validations

    Raji cells were subjected to SDS PAGE followed by western blot with Catalog No:109645(CXCR7 antibody) at dilution of 1:500

    Raji cells were subjected to SDS PAGE followed by western blot with Catalog No:109645(CXCR7 antibody) at dilution of 1:500

    IP Result of anti-CXCR7 (IP:Catalog No:109645, 3ug; Detection:Catalog No:109645 1:500) with HUVEC cells lysate 1400ug.

    IP Result of anti-CXCR7 (IP:Catalog No:109645, 3ug; Detection:Catalog No:109645 1:500) with HUVEC cells lysate 1400ug.

    1X10^6 Raji cells were stained with 0.2ug CXCR7 antibody (Catalog No:109645, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1000.

    1X10^6 Raji cells were stained with 0.2ug CXCR7 antibody (Catalog No:109645, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1000.

  • Background
    CXCR7 (C-X-C chemokine receptor type 7), also known as RDC1, is a member of the G-protein coupled receptor family. CXCR7 can bind the chemokines CXCL11 and CXCL12 with high affinity, and it also acts as coreceptor with CXCR4 for a restricted number of HIV isolates. Expression of CXCR7 has been associated with cardiac development as well as with tumor growth and progression. This antibody recognizes endogenous CXCR7, which has an experimentally determined molecular weight of 50 kDa (PMID: 20197403; 20388803).
  • References
    • Salazar N, Muñoz D, Kallifatidis G, Singh RK, Jordà M, Lokeshwar BL. The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation. Molecular cancer. 13:198. 2014.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"