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CXCR4 antibody

Cat.#: 109644

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Product Information

  • Product Name
    CXCR4 antibody
  • Documents
  • Description
    CXCR4 Rabbit Polyclonal antibody. Positive IP detected in HeLa cells. Positive WB detected in rat spleen tissue, HeLa cells, Jurkat cells. Observed molecular weight by Western-blot: 60-70kd
  • Tested applications
    ELISA, IP, WB
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    CD184 antibody; CXC R4 antibody; CXCR 4 antibody; CXCR4 antibody; CXCR4B antibody; D2S201E antibody; FB22 antibody; Fusin antibody; HM89 antibody; HSY3RR antibody; LAP3 antibody; LCR1 antibody; LESTR antibody; SDF 1 receptor antibody; WHIM antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of CXCR4 recombinant protein (Accession Number: NM_003467). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:200-1:2000

  • Validations

    IP Result of anti-CXCR4 (IP:Catalog No:109644, 3ug; Detection:Catalog No:109644 1:500) with HeLa cells lysate 1000ug.

    IP Result of anti-CXCR4 (IP:Catalog No:109644, 3ug; Detection:Catalog No:109644 1:500) with HeLa cells lysate 1000ug.

    rat spleen tissue were subjected to SDS PAGE followed by western blot with Catalog No:109644(CXCR4 Antibody) at dilution of 1:1000

    rat spleen tissue were subjected to SDS PAGE followed by western blot with Catalog No:109644(CXCR4 Antibody) at dilution of 1:1000

  • Background
    The chemokine receptor CXCR4, a 7-transmembrane protein on cell surface, acts with the CD4 protein to support HIV entry into cells. CXCR4 is highly expressed in brain and heart, white blood cells, vascular endothelial cells, and umbilical cord endothelial cells. Several CXCR4 isoforms have been identified with molecular weights of 47, 50, 62 and 98kDa. The 62-64kDa CXCR4 is predominantly ubiquitinated and is preferentially associated with CD4.
  • References
    • Wang J, Yu L, Jiang C. Cerebral ischemia increases bone marrow CD4+CD25+FoxP3+ regulatory T cells in mice via signals from sympathetic nervous system. Brain, behavior, and immunity. 43:172-83. 2015.
    • Bi J, Li P, Li C. The SDF-1/CXCR4 chemokine axis in uveal melanoma cell proliferation and migration. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"