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Product Name
CXCR3B-specific antibody
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Description
CXCR3B-specific Mouse Monoclonal antibody. Positive WB detected in Hela cells, Jurkat cells, U-937 cells. Observed molecular weight by Western-blot: 40kd+43kd
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Tested applications
ELISA, WB
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Species reactivity
Human; other species not tested.
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Alternative names
CD183 antibody; CKR L2 antibody; CMKAR3 antibody; CXC R3 antibody; CXCR 3 antibody; CXCR3 antibody; CXCR3A antibody; CXCR3B antibody; G protein coupled receptor 9 antibody; GPR9 antibody; IP 10 receptor antibody; IP10 R antibody; Mig R antibody; MigR antibody
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Isotype
Mouse IgG2b
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: AF469635). Purification method: Caprylic acid/ammonium sulfate precipitation.
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Clonality
Monoclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:107186(CXCR3B antibody) at dilution of 1:1000
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Background
CXCR3 (C-X-C chemokine receptor type 3) is a G protein-coupled, seven-transmembrane domain chemokine receptor that is expressed on the surface of a number of cell types, including activated CD4+ and CD8+ T cells, NK and NK-T cells, plasmacytoid dendritic cells, and some B cells (PMID: 16847335). CXCR3 binds and is activated by the three IFN-gamma-inducible chemokines: CXCL9, CXCL10, and CXCL11. Binding of these ligands to CXCR3 has been implicated in regulating T-cell infiltration during inflammation and tissue injury (PMID: 17250586). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms, CXCR3B, mediates the angiostatic activity of CXCR3 ligands and also acts as functional receptor for CXCL4 (PMID:12782716). This monoclonal antibody is specific to CXCR3B.
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References
- Bodnar RJ, Rodgers ME, Chen WC, Wells A. Pericyte regulation of vascular remodeling through the CXC receptor 3. Arteriosclerosis, thrombosis, and vascular biology. 33(12):2818-29. 2013.
- Balan M, Pal S. A novel CXCR3-B chemokine receptor-induced growth-inhibitory signal in cancer cells is mediated through the regulation of Bach-1 protein and Nrf2 protein nuclear translocation. The Journal of biological chemistry. 289(6):3126-37. 2014.
- Bodnar RJ, Wells A. Differential regulation of pericyte function by the CXC receptor 3. Wound repair and regeneration : official publication of the Wound Healing Society
- Hu M, Li K, Maskey N. Overexpression of the chemokine receptor CXCR3 and its correlation with favorable prognosis in gastric cancer. Human pathology. 46(12):1872-80. 2015.
- Wu Q, Dhir R, Wells A. Altered CXCR3 isoform expression regulates prostate cancer cell migration and invasion. Molecular cancer. 11:3. 2012.
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