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CXCL12 antibody

Cat.#: 109637

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Special Price 239.0 USD

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Product Information

  • Product Name
    CXCL12 antibody
  • Documents
  • Description
    CXCL12 Rabbit Polyclonal antibody. Positive IHC detected in human liver cancer tissue, human tonsillitis tissue.
  • Tested applications
    ELISA, IHC
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    C X C motif chemokine 12 antibody; CXCL12 antibody; hIRH antibody; hSDF 1 antibody; IRH antibody; PBSF antibody; SCYB12 antibody; SDF 1 antibody; SDF 1a antibody; SDF 1b antibody; SDF1 antibody; SDF1A antibody; SDF1B antibody; Stromal cell derived factor 1 antibody; TLSF a antibody; TLSF b antibody; TPAR1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of CXCL12 recombinant protein (Accession Number: NM_199168). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    IHC: 1:20-1:200

  • Validations

    Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using Catalog No:109637(CXCL12 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using Catalog No:109637(CXCL12 Antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using Catalog No:109637(CXCL12 Antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using Catalog No:109637(CXCL12 Antibody) at dilution of 1:50 (under 40x lens)

  • Background
    In adulthood, CXCL12 plays an important role in angiogenesis by recruiting endothelial progenitor cells (EPCs) from the bone marrow through a CXCR4 dependent mechanism (PMID: 17878755). It is this function of CXCL12 that makes it a very important factor in carcinogenesis and the neovascularisation linked to tumour progression (PMID: 16943240). CXCL12 also has a role in tumor metastasis where cancer cells that express the receptor CXCR4 are attracted to metastasis target tissues that release the ligand, CXCL12 (PMID: 11242036 ). In breast cancer, however, increased expression of CXCL12 determines a reduced risk of distant metastasis (PMID: 19646861; 17724466 ).
  • References
    • Yang S, Yang TS, Wang F, Su SB. High-mobility group box-1-Toll-Like receptor 4 axis mediates the recruitment of endothelial progenitor cells in alkali-induced corneal neovascularization. International immunopharmacology. 28(1):450-8. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"