CTNS antibody

CTNS antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CTNS Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer. Positive WB detected in HEK-293 cells, HeLa cells, HepG2 cells. Observed molecular weight by Western-blot: 45kd

ELISA, WB, IHC

human, mouse, rat; other species not tested.

CTNS antibody; CTNS LSB antibody; Cystinosin antibody; cystinosis antibody; nephropathic antibody; PQLC4 antibody

Rabbit IgG

This antibody was obtained by immunization of CTNS recombinant protein (Accession Number: XM_005256485). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The CTNS or cystinosin is a lysosomal membrane protein which comprises with seven transmembrane domains, a 128 amino acid N-terminal region bearing seven N-glycosylation sites and a cytosolic C-terminal GYDQL sorting motif. It functions as a H+-driven cystine transporter responsible for cystine export from lysosomes. The mutation of CTNS gene cause an inherited disorder, cystinosis, characterized by defective lysosomal efflux of cystine. This antibody was raised against the N-terminal region of human cystinosin. Two isoforms of CTNS exist due to alternative splicing events and both of them can be detected through this antibody.