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Product Name
CTDSPL2 antibody
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Description
CTDSPL2 Rabbit Polyclonal antibody. Positive IHC detected in human endometrial cancer tissue, human testis tissue. Positive WB detected in MCF7 cells, HeLa cells, HepG2 cells, human brain tissue, mouse eye tissue, mouse testis tissue, Y79 cells. Positive IP detected in mouse testis tissue. Observed molecular weight by Western-blot: 67 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CTDSP like 2 antibody; CTDSPL2 antibody; FLJ10523 antibody; HSPC058 antibody; HSPC129 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of CTDSPL2 recombinant protein (Accession Number: XM_006720565). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
MCF7 cells were subjected to SDS PAGE followed by western blot with Catalog No:109722(CTDSPL2 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human endometrial cancer using Catalog No:109722(CTDSPL2 antibody) at dilution of 1:100 (under 40x lens)
IP Result of anti-CTDSPL2 (IP:Catalog No:109722, 4ug; Detection:Catalog No:109722 1:500) with mouse testis tissue lysate 4400ug.
Immunohistochemistry of paraffin-embedded human testis tissue slide using Catalog No:109722(CTDSPL2 Antibody) at dilution of 1:50 (under 40x lens)
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Background
CTD small phosphatase-like protein 2 (CTDSPL2) is also named as HSPC058 and HSPC129, belongs to the CTDSPL2 family. It is a putative RNA-polymerase II carboxy-terminal domain (CTD) phosphatase, whose specific CTD phosphatase activity was verified in vitro, and may regulate the dynamic phosphorylation of RNAP II CTD.( PMID: 17487459) It can obviously improve the expression of ε- and γ-globin genes in K562 cells and CD34+ cells derived from UCB.( PMID: 20932329) This antibody is a rabbit polyclonal antibody raised against a region of human CTDSPL2.
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References
- Ma YN, Zhang X, Yu HC, Zhang JW. CTD small phosphatase like 2 (CTDSPL2) can increase ε- and γ-globin gene expression in K562 cells and CD34+ cells derived from umbilical cord blood. BMC cell biology. 11:75. 2010.
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