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Product Name
CRX antibody
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Description
CRX Rabbit Polyclonal antibody. Positive IP detected in Y79 cells. Positive WB detected in Y79 cells. Observed molecular weight by Western-blot: 37 kDa
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Tested applications
ELISA, WB, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
cone rod homeobox antibody; Cone rod homeobox protein antibody; CORD2 antibody; CRD antibody; CRX antibody; LCA7 antibody; OTX3 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of CRX recombinant protein (Accession Number: NM_000554). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IP: 1:200-1:2000
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Validations
Y79 cells were subjected to SDS PAGE followed by western blot with Catalog No:109582(CRX antibody) at dilution of 1:500
IP Result of anti-CRX (IP:Catalog No:109582, 4ug; Detection:Catalog No:109582 1:500) with Y79 cells lysate 1920ug.
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Background
Cone-rod homeobox (Crx) is a homeodomain transcription factor and member of the Otx family, which has been thought to play a critical role in determining and maintaining the phenotype of both pinealocytes and retinal photoreceptors [PMID:17467693]. In the mammalian retina, Crx plays an essential role in the normal development and maintenance of cones and rods and regulates expression of the network of genes that characterize the retina [PMID:17653270]. Elimination of Crx by disruption of the homeobox domain results in loss of the image-forming visual system but not the non-image-forming visual system controlling circadian rhythms [PMID:20438719].
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References
- Masuda T, Zhang X, Berlinicke C. The transcription factor GTF2IRD1 regulates the topology and function of photoreceptors by modulating photoreceptor gene expression across the retina. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(46):15356-68. 2014.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"