CRTC1 Monoclonal Antibody

CRTC1 Monoclonal Antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Monoclonal antibody to CRTC1

WB, ICC

Human, Mouse, Rat, Monkey

CRTC1 antibody; MECT1 antibody; TORC-1 antibody; TORC1 antibody; WAMTP1 antibody; CREB-regulated transcription coactivator 1 antibody

Mouse IgG

Antigen: Recombinant protein of human CRTC1

Monoclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Store at -20℃. Avoid freeze / thaw cycles.

WB 1:1000 - 1:4000
ICC 1:50 - 1:200

Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock.; (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).