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Product Name
CRHR1 antibody
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Description
CRHR1 Rabbit Polyclonal antibody. Positive WB detected in SH-SY5Y cells. Observed molecular weight by Western-blot: 46 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human; other species not tested.
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Alternative names
CRF R antibody; CRF R 1 antibody; CRF R1 antibody; CRF1 antibody; CRFR antibody; CRFR 1 antibody; CRFR1 antibody; CRH R 1 antibody; CRH R1 antibody; CRH R1h antibody; CRHR antibody; CRHR1 antibody; CRHR1f antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_004382). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:1000
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Validations
SH-SY5Y cells were subjected to SDS PAGE followed by western blot with Catalog No:109557(CRHR1 Antibody) at dilution of 1:100
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Background
Corticotropin-releasing hormone (CRH, also known as Corticotropin-releasing factor, CRF) is a 41 amino acid peptide hormone and a key regulator of the stress response. CRH and the related urocortin peptides (UCN, UCN2 and UCN3) mediate their actions through two mammalian receptor subtypes, CRHR1 and CRHR2 (PMID: 23863939). CRHR1 (also known as CRFR1) exhibits high affinity towards CRH and UCN but low affinity towards UCN2 and no affinity towards UCN3 (PMID: 22684850). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Widely distributed through out the brain, CRHR1 critically controls behavioral adaptation to stress and is causally linked to emotional disorders (PMID: 21885734).
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References
- Chen SJ, Yang JF, Kong FP. Overactivation of corticotropin-releasing factor receptor type 1 and aquaporin-4 by hypoxia induces cerebral edema. Proceedings of the National Academy of Sciences of the United States of America. 111(36):13199-204. 2014.
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