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CRAT antibody

Cat.#: 109538

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Product Information

  • Product Name
    CRAT antibody
  • Documents
  • Description
    CRAT Rabbit Polyclonal antibody. Positive WB detected in human heart tissue, mouse skeletal muscle tissue. Positive IP detected in mouse skeletal muscle tissue. Observed molecular weight by Western-blot: 55-68 kDa
  • Tested applications
    ELISA, WB, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    CACP antibody; Carnitine acetylase antibody; carnitine acetyltransferase antibody; Carnitine O acetyltransferase antibody; CAT antibody; CAT1 antibody; CRAT antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of CRAT recombinant protein (Accession Number: NM_144782). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IP: 1:200-1:1000

  • Validations

    human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:109538(CRAT antibody) at dilution of 1:300

    human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:109538(CRAT antibody) at dilution of 1:300

    IP Result of anti-CRAT (IP:Catalog No:109538, 4ug; Detection:Catalog No:109538 1:300) with mouse skeletal muscle tissue lysate 3600ug.

    IP Result of anti-CRAT (IP:Catalog No:109538, 4ug; Detection:Catalog No:109538 1:300) with mouse skeletal muscle tissue lysate 3600ug.

  • Background
    CRAT, also named as CAT1, belongs to the carnitine/choline acetyltransferase family. It is specific for short chain fatty acids. CRAT seems to affect the flux through the pyruvate dehydrogenase complex. It may be involved as well in the transport of acetyl-CoA into mitochondria. Carnitine palmitoyltransferase (CPT) deficiencies are common disorders of mitochondrial fatty acid oxidation. The CPT system is made up of two separate proteins located in the outer (CPT1) and inner (CPT2) mitochondrial membranes. CRAT is an active forms for carnitine acetyltransferase. This antibody can bind the close sequences genes.
  • References
    • Sharma S, Sun X, Agarwal S. Role of carnitine acetyl transferase in regulation of nitric oxide signaling in pulmonary arterial endothelial cells. International journal of molecular sciences. 14(1):255-72. 2012.
    • Sun X, Sharma S, Fratz S. Disruption of endothelial cell mitochondrial bioenergetics in lambs with increased pulmonary blood flow. Antioxidants & redox signaling. 18(14):1739-52. 2013.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"