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CRABP2 antibody

Cat.#: 109537

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Product Information

  • Product Name
    CRABP2 antibody
  • Documents
  • Description
    CRABP2 Rabbit Polyclonal antibody. Positive IHC detected in human colon cancer tissue, human skin tissue. Positive IP detected in HeLa cells. Positive WB detected in HeLa cells. Observed molecular weight by Western-blot: 16kd
  • Tested applications
    ELISA, WB, IHC, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    CRABP II antibody; CRABP2 antibody; RBP6 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of CRABP2 recombinant protein (Accession Number: NM_001199723). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:200-1:1000

    IHC: 1:20-1:200

  • Validations

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:109537(CRABP2 antibody) at dilution of 1:500

    HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:109537(CRABP2 antibody) at dilution of 1:500

    IP Result of anti-CRABP2 (IP:Catalog No:109537, 3ug; Detection:Catalog No:109537 1:300) with HeLa cells lysate 4650ug.

    IP Result of anti-CRABP2 (IP:Catalog No:109537, 3ug; Detection:Catalog No:109537 1:300) with HeLa cells lysate 4650ug.

    Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:109537(CRABP2 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:109537(CRABP2 antibody) at dilution of 1:50 (under 10x lens)

  • Background
    Cellular retinoic acid binding protein 2 (CRABP2, synonyms: RBP6, CRABP-II). A number of specific carrier proteins for members of the vitamin A family have been discovered. Cellular retinoic acid binding proteins (CRABP) are low molecular weight proteins whose precise function remains unknown. CRABP2 is important in retinoic acid-mediated regulation of human skin growth and differentiation. It has been postulated that the CRABP2 gene is transcriptionally regulated by a newly synthesized regulatory protein.
  • References
    • Fu YS, Wang Q, Ma JX. CRABP-II methylation: a critical determinant of retinoic acid resistance of medulloblastoma cells. Molecular oncology. 6(1):48-61. 2012.
    • Persaud SD, Lin YW, Wu CY, Kagechika H, Wei LN. Cellular retinoic acid binding protein I mediates rapid non-canonical activation of ERK1/2 by all-trans retinoic acid. Cellular signalling. 25(1):19-25. 2013.
    • Kretzschmar K, Cottle DL, Donati G. BLIMP1 is required for postnatal epidermal homeostasis but does not define a sebaceous gland progenitor under steady-state conditions. Stem cell reports. 3(4):620-33. 2014.
    • Xia SL, Wu ML, Li H. CRABP-II- and FABP5-independent responsiveness of human glioblastoma cells to all-trans retinoic acid. Oncotarget. 6(8):5889-902. 2015.
    • Doupé DP, Alcolea MP, Roshan A. A single progenitor population switches behavior to maintain and repair esophageal epithelium. Science (New York, N.Y.). 337(6098):1091-3. 2012.
    • Goto M, Hojo M, Ando M. Hes1 and Hes5 are required for differentiation of pituicytes and formation of the neurohypophysis in pituitary development. Brain research. 1625:206-17. 2015.
    • Collins CA, Watt FM. Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for beta-catenin and Notch signalling. Developmental biology. 324(1):55-67. 2008.
    • Chen N, Sun W, Deng X. Quantitative proteome analysis of HCC cell lines with different metastatic potentials by SILAC. Proteomics. 8(23-24):5108-18. 2008.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"