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Product Name
CRABP1 antibody
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Description
CRABP1 Rabbit Polyclonal antibody. Positive WB detected in human spleen tissue, Transfected HEK-293 cells. Observed molecular weight by Western-blot: 15kd
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CRABP antibody; CRABP I antibody; CRABP1 antibody; CRABPI antibody; RBP5 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of CRABP1 recombinant protein (Accession Number: NM_004378). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:300-1:1500
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Validations
human spleen tissue were subjected to SDS PAGE followed by western blot with Catalog No:109536(CRABP1 antibody) at dilution of 1:500
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Background
The cellular retinoic acid-binding proteins including CRABP1 and CRABP2 bind retinoic acid (RA), an important regulator of cell growth and differentiation, thus play an important role in RA-mediated differentiation and proliferation processes. It has been reported that CRABP1 influences the biological effects of RA in cell-selective manners by enhancing the physiological function of RA in keratinocytes or inhibiting RA-induced differentiation of neuroblastoma cells.
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References
- Fu YS, Wang Q, Ma JX. CRABP-II methylation: a critical determinant of retinoic acid resistance of medulloblastoma cells. Molecular oncology. 6(1):48-61. 2012.
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