CPSF6 antibody

CPSF6 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CPSF6 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, Jurkat cells, PC-3 cells. Positive IP detected in HeLa cells. Positive IHC detected in human kidney tissue, human heart tissue. Observed molecular weight by Western-blot: 55-68kd

ELISA, WB, IHC, IP

Human,Mouse,Rat; other species not tested.

CFIM antibody; CFIM68 antibody; CPSF 68 kDa subunit antibody; CPSF6 antibody; HPBRII 4 antibody; HPBRII 7 antibody; Protein HPBRII 4/7 antibody

Rabbit IgG

This antibody was obtained by immunization of CPSF6 recombinant protein (Accession Number: NM_001300947). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The binding of Cleavage factor Im (CFIM), also known as CPSF6, to the pre-mRNA is one of the earliest steps in the assembly of the cleavage and polyadenylation machinery and facilitates the recruitment of other processing factors. CFIM is required for the first step in pre-mRNA 3′-end processing and can be reconstituted in vitro from its heterologously expressed 25- and 68-kDa subunits. It involved in RNA binding, protein-protein interactions, and subcellular localization [PMID:15169763]. In addition, it is a pre-mRNA processing protein that dynamically shuttles between the nucleus and the cytoplasm and contains a C-terminal nuclear-targeting arginine/serine-rich (RS-) domain of the type bound by TNPO3[PMID:15169763,19864460].

• Henning MS, Dubose BN, Burse MJ, Aiken C, Yamashita M. In vivo functions of CPSF6 for HIV-1 as revealed by HIV-1 capsid evolution in HLA-B27-positive subjects. PLoS pathogens. 10(1):e1003868. 2014.