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COX7A1 antibody

Cat.#: 109497

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Product Information

  • Product Name
    COX7A1 antibody
  • Documents
  • Description
    COX7A1 Rabbit Polyclonal antibody. Positive IHC detected in human gliomas tissue. Positive WB detected in mouse heart tissue, human brain tissue, human kidney tissue. Observed molecular weight by Western-blot: 7-9kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    COX7A antibody; COX7A1 antibody; COX7AH antibody; COX7AM antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of COX7A1 recombinant protein (Accession Number: NM_001864). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    mouse heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:109497(COX7A1 antibody) at dilution of 1:1000

    mouse heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:109497(COX7A1 antibody) at dilution of 1:1000

    Immunohistochemical of paraffin-embedded human gliomas using Catalog No:109497(COX7A1 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human gliomas using Catalog No:109497(COX7A1 antibody) at dilution of 1:100 (under 10x lens)

  • Background
    Cytochrome c oxidase(COX) catalyzes the transfer of electrons from reduced cytochrome c to molecular oxygen. Subunit VIIa of mammalian COX exists in at least 2 isoforms, liver and muscle. COX7A1(Cytochrome c oxidase subunit 7A1, mitochondrial) is also named as COX7AH, cytochrome c oxidase subunit VIIa-H, cytochrome c oxidase subunit VIIa-M and is the muscle isoform of COX subunit VIIa. Northern-blot analysis of primate tissues demonstrated that COXVIIa-M mRNA is present only in muscle tissues(PMID:1327965).
  • References
    • Oliva CR, Nozell SE, Diers A. Acquisition of temozolomide chemoresistance in gliomas leads to remodeling of mitochondrial electron transport chain. The Journal of biological chemistry. 285(51):39759-67. 2010.
    • Boczonadi V, Giunta M, Lane M, Tulinius M, Schara U, Horvath R. Investigating the role of the physiological isoform switch of cytochrome c oxidase subunits in reversible mitochondrial disease. The international journal of biochemistry & cell biology. 63:32-40. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"