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COPS7A antibody

Cat.#: 109465

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Product Information

  • Product Name
    COPS7A antibody
  • Documents
  • Description
    COPS7A Rabbit Polyclonal antibody. Positive WB detected in human heart tissue, human brain tissue, human kidney tissue, mouse kidney tissue. Positive IP detected in mouse heart tissue. Positive IHC detected in human kidney tissue, human heart tissue, human liver tissue, human lung tissue, human ovary tissue, human placenta tissue, human skin tissue, human spleen tissue, human testis tissue. Observed molecular weight by Western-blot: 30 kDa
  • Tested applications
    ELISA, WB, IHC, IP
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    COPS7A antibody; CSN7A antibody; DERP10 antibody; SGN7a antibody; Signalosome subunit 7a antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of COPS7A recombinant protein (Accession Number: NM_016319). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IP: 1:200-1:1000

    IHC: 1:20-1:200

  • Validations

    human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:109465(COPS7A antibody) at dilution of 1:300

    human heart tissue were subjected to SDS PAGE followed by western blot with Catalog No:109465(COPS7A antibody) at dilution of 1:300

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:109465(COPS7A antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:109465(COPS7A antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:109465(COPS7A antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human kidney using Catalog No:109465(COPS7A antibody) at dilution of 1:50 (under 40x lens)

    IP Result of anti-COPS7A (IP:Catalog No:109465, 4ug; Detection:Catalog No:109465 1:300) with mouse heart tissue lysate 4000ug.

    IP Result of anti-COPS7A (IP:Catalog No:109465, 4ug; Detection:Catalog No:109465 1:300) with mouse heart tissue lysate 4000ug.

  • Background
    COPS7A is component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. COPS7A was consistently expressed in oligodendrocyte lineage cells, and was down-regulated during the peak period of myelination. COPS7A associated physically with Olig1, and it might thus serve as a novel negative regulator in oligodendrocytes differentiation.
  • References
    • Zhou J, Li Y, He C. Identification of the Interaction Between the Human Homologue of the Arabidopsis COP9 Signalosome Subunit 7a and Olig1. Cellular and molecular neurobiology. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"