-
Product Name
Complement factor H antibody
- Documents
-
Description
Complement factor H Rabbit Polyclonal antibody. Positive WB detected in human blood tissue. Positive IP detected in human plasma tissue. Observed molecular weight by Western-blot: 150 kDa
-
Tested applications
ELISA, WB, IP
-
Species reactivity
Human; other species not tested.
-
Alternative names
ARMD4 antibody; ARMS1 antibody; CFH antibody; CFHL3 antibody; Complement factor H antibody; Factor H antibody; FHL1 antibody; H factor 1 antibody; HF1 antibody; HF2 antibody; HUS antibody
-
Isotype
Rabbit IgG
-
Preparation
This antibody was obtained by immunization of Complement factor H recombinant protein (Accession Number: NM_001014975). Purification method: Antigen affinity purified.
-
Clonality
Polyclonal
-
Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
-
Storage instructions
Store at -20℃. DO NOT ALIQUOT
-
Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:500-1:5000
-
Validations
human blood tissue were subjected to SDS PAGE followed by western blot with Catalog No:109447(CFH Antibody) at dilution of 1:1000
IP Result of anti-CFH (IP:Catalog No:109447, 4ug; Detection:Catalog No:109447 1:1000) with human plasma tissue lysate 4000ug.
-
Background
Complement factor H (CFH) is an abundant plasma glycoprotein that regulates the function of the alternative complement pathway in fluid phase and on cellular surfaces (PMID: 2963625). Factor H binds to C3b, accelerates the decay of the alternative pathway C3-convertase (C3bBb) and acts as a cofactor for the factor I-mediated proteolytic inactivation of C3b (PMID: 15163532). It plays a critical role in the homeostasis of the complement system in plasma and in the protection of bystander host cells and tissues from damage by complement activation. Abnormalities in factor H have been associated with renal disease (PMID: 18190458).
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"