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Product Name
CNGA4 Polyclonal Antibody
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Description
Polyclonal antibody to CNGA4
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Tested applications
WB
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Species reactivity
Human, Mouse
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Alternative names
CNGA4 antibody; CNCA2 antibody; CNG-4 antibody; CNG4 antibody; CNG5 antibody; CNGB2 antibody; OCNC2 antibody; OCNCBETA antibody; OCNCb antibody; cyclic nucleotide gated channel alpha 4 antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 416-575 of human CNGA4 (NP_001032406.1).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:2000
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Validations
Western blot - CNGA4 Polyclonal Antibody
Western blot analysis of extracts of various cell lines, using CNGA4 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit .Exposure time: 90s.
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Background
Second messenger, cAMP, causes the opening of cation-selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of this channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation. By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity).
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"