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Product Name
CLEC2D antibody
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Description
CLEC2D Rabbit Polyclonal antibody. Positive WB detected in Jurkat cells. Observed molecular weight by Western-blot: 33 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human; other species not tested.
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Alternative names
CLAX antibody; CLEC2D antibody; Lectin like NK cell receptor antibody; Lectin like transcript 1 antibody; LLT 1 antibody; LLT1 antibody; OCIL antibody; OsteOClast inhibitory lectin antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of CLEC2D recombinant protein (Accession Number: BC019883). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:109352(CLEC2D antibody) at dilution of 1:500
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Background
CLEC2D (C-type lectin domain family 2 member D), also known as LLT1 (lectin-like transcript 1) or ocIL (Osteoclast inhibitory lectin), is a single-pass type II membrane protein expressed by hematopoietic cells and osteoblasts (PMID: 21930700; 14753741). Its expression was found to be tightly correlated with activation on T cells, NK cells, B cells, and DCs (PMID: 21930700). CLEC2D is a ligand for the human NKR-P1A (CD161) receptor and that their interaction differentially regulates NK- and T-cell functions (PMID: 16339513, 16339512). It inhibits the formation and function of osteoclasts and modulates the release of interferon-gamma by human NK cells (PMID:14753741; 20415786).
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