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Claudin 1 antibody

Cat.#: 109336

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Product Information

  • Product Name
    Claudin 1 antibody
  • Documents
  • Description
    Claudin 1 Rabbit Polyclonal antibody. Positive WB detected in mouse skin tissue, mouse liver tissue, mouse thymus tissue. Positive IHC detected in human skin tissue, human cervical cancer tissue, human liver tissue, human oesophagus cancer tissue, human skin cancer tissue, mouse colon tissue. Observed molecular weight by Western-blot: 23-25 kDa
  • Tested applications
    ELISA, IHC, WB
  • Species reactivity
    Human, Mouse; other species not tested.
  • Alternative names
    claudin 1 antibody; CLD1 antibody; CLDN1 antibody; ILVASC antibody; SEMP1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Claudin 1 recombinant protein (Accession Number: NM_021101). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    Immunohistochemical of paraffin-embedded human skin using Catalog No:109336(CLDN1 antibody) at dilution of 1:50 (under 40x lens)

    Immunohistochemical of paraffin-embedded human skin using Catalog No:109336(CLDN1 antibody) at dilution of 1:50 (under 40x lens)

    mouse skin tissue were subjected to SDS PAGE followed by western blot with Catalog No:109336(Claudin 1 Antibody) at dilution of 1:600

    mouse skin tissue were subjected to SDS PAGE followed by western blot with Catalog No:109336(Claudin 1 Antibody) at dilution of 1:600

  • Background
    Claudins are a family of proteins that are the most important components of the tight junctions, where they establish the paracellular barrier that controls the flow of molecules in the intercellular space between the cells of an epithelium. 23 claudins have been identified. They are small (20-27 kilodalton (kDa)) proteins with very similar structure. They have four transmembrane domains, with the N-terminus and the C-terminus in the cytoplasm. Claudin-1 is expressed primarily in keratinocytes and normal mammary epithelial cells.
  • References
    • Han J, Liu L, Yu N. Polysaccharides from Acanthopanax senticosus enhances intestinal integrity through inhibiting TLR4/NF-κB signaling pathways in lipopolysaccharide-challenged mice. Animal science journal = Nihon chikusan Gakkaiho. 2015.
    • Han J, Xu Y, Yang D, Yu N, Bai Z, Bian L. Effect of Polysaccharides from Acanthopanax senticosus on Intestinal Mucosal Barrier of Escherichia coli Lipopolysaccharide Challenged Mice. Asian-Australasian journal of animal sciences. 29(1):134-41. 2016.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"