CITED2 antibody

CITED2 antibody

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CITED2 Rabbit Polyclonal antibody. Positive WB detected in SH-SY5Y cells, mouse brain tissue. Positive IF detected in SH-SY5Y cells. Observed molecular weight by Western-blot: 24 kDa

ELISA, WB, IF

Human,Mouse,Rat; other species not tested.

CITED2 antibody; MRG 1 antibody; MRG1 antibody; MSG related protein 1 antibody; P35SRJ antibody

Rabbit IgG

This antibody was obtained by immunization of CITED2 recombinant protein (Accession Number: NM_001168388). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

CITED2, also named as P35srj, is a cAMP-responsive element-binding protein (CBP)/p300-transactivator, with an ED(Glu/Asp)-rich C-terminal domain that acts as an important modulator in the development of the heart [PMID:10552932]. There are two isoforms of CITED2 protein and the calculated molecular weight of them are 24kDa and 28 kDa. The 28kDa isoform having modification site may migrate to 35 kDa. It is proposed to be a negative regulator of HIF-1α through its competitive binding to the CH1 domain of CBP/p300, which mediated signaling and to a decrease in HIF-1-responsive genes such as VEGF [PMID:9887100]. In addition, it is also a co-activator of the transcriptional activity of the TFAP2 isoform, which is an extensively expressed nuclear protein with functions in embryogenesis, inflammation, and stress responses[PMID:22735262].