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Mouse CNTF/Ciliary Neurotrophic Factor (His Tag) recombinant protein

Cat.#: 502341

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Product Information

  • Product Name
    Mouse CNTF/Ciliary Neurotrophic Factor (His Tag) recombinant protein
  • Documents
  • Description
    CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
  • Protein name
    Ciliary neurotrophic factor
  • Protein short names
    CNTF; MGC41235; HCNTF; AI429687
  • Uniprot ID
    Q544D1
  • Gene Name
    Cntf
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    A DNA sequence encoding the mouse CNTF (NP_740756.1) (Ala2-Met198) was expressed with a polyhistidine tag at the N-terminus.
  • Protein Species
    Mouse
  • Molecular weight
    The recombinant mouse CNTF consists of 215 amino acids and predicts a molecular mass of 24.7 KDa. It migrates as an approximately 25 KDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Activity
    1. Measured by its binding ability in a functional ELISA. Immobilized mouse CNTF (cat:502341) at 10 μg/ml (100 μl/well) can bind biotinylated rat CNTFR-His (Cat:501299). The EC50 of biotinylated rat CNTFR-His (Cat:501299) is 5-12 ng/ml.
    2. Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is typically 0.1-0.5 μg/mL.
  • Validations

    Mouse CNTF / Ciliary Neurotrophic Factor Protein (His Tag) SDS-PAGE

    Mouse CNTF / Ciliary Neurotrophic Factor Protein (His Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"