Mouse CHI3L1/YKL40 (His Tag) recombinant protein

Mouse CHI3L1/YKL40 (His Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.

Chitinase-3-like protein 1

FLJ38139; DKFZP686N19119; GP39; ASRT7; HC-GP39; BRP39; HCGP-3P; CHI3L1; AW208766; YKL40; YYL-40

Q61362

Chi3l1; Brp39; Chil1

Human Cells

A DNA sequence encoding the extracellular domain of mouse CHI3L1 (Q61362) (Met 1-Ala 381) was expressed, with a C-terminal polyhistidine tag.

Mouse

The secreted recombinant mouse CHI3L1 comprises 371 amino acids and has a calculated molecular mass of 42.3 kDa. As a result of glycosylation, the apparent molecular mass of rmCHI3L1 is approximately 50 kDa in SDS-PAGE under reducing conditions.

> 97 % as determined by SDS-PAGE