• α-CGRP (human) peptide

α-CGRP (human) peptide

Not For Human Use, Lab Use Only.

Cat.#: 318964

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Product Information

  • Product Name
    α-CGRP (human) peptide
  • Documents
  • Sequence Shortening
    H-ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2
  • Sequence
    H-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2
  • Length (aa)
    37
  • Peptide Purity (HPLC)
    95.19%
  • Molecular Formula
    C163H267N51O49S2
  • Molecular Weight
    3789.29
  • Source
    Synthetic
  • Form
    Powder
  • Description
    α-Calcitonin gene related peptide (human) is a potent, long-lasting vasodilator which possesses protective mechanisms for physiological and pathological conditions involving the cardiovascular system and wound healing. CGRP is primarily released from sensory nerves and can function in the transmission of nociception. α-Calcitonin gene related peptide (human) acts as an appetite suppressant and contributes to gastric acid secretion.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
  • References
    • Brain et al (1985) Calcitonin gene-related peptide is a potent vasodilator. Nature 313 54 PMID: 3917554
    • Poyner et al (2002) International union of pharmacology XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol.Revs. 54 233 PMID: 12037140
    • Russell et al (2014) Calcitonin gene-related peptide: physiology and pathophysiology. Physiol Rev. 94(4) 1099 PMID: 25287861
  • About TFA salt

    Trifluoroacetic acid (TFA) has a significant impact on peptides due to its role in the peptide synthesis process.

    TFA is essential for the protonation of peptides that lack basic amino acids such as Arginine (Arg), Histidine (His), and Lysine (Lys), or ones that have blocked N-termini. As a result, peptides often contain TFA salts in the final product.

    TFA residues, when present in custom peptides, can cause unpredictable fluctuations in experimental data. At a nanomolar (nM) level, TFA can influence cell experiments, hindering cell growth at low concentrations (as low as 10 nM) and promoting it at higher doses (0.5–7.0 mM). It can also serve as an allosteric regulator on the GlyR of glycine receptors, thereby increasing receptor activity at lower glycine concentrations.

    In an in vivo setting, TFA can trifluoroacetylate amino groups in proteins and phospholipids, inducing potentially unwanted antibody responses. Moreover, TFA can impact structure studies as it affects spectrum absorption.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"