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Product Name
CFLAR Polyclonal Antibody
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Description
Polyclonal antibody to CFLAR
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Tested applications
WB, IHC
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Species reactivity
Human, Mouse, Rat
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Alternative names
CFLAR antibody; CASH antibody; CASP8AP1 antibody; CLARP antibody; Casper antibody; FLAME antibody; FLAME-1 antibody; FLAME1 antibody; FLIP antibody; I-FLICE antibody; MRIT antibody; c-FLIP antibody; c-FLIPL antibody; c-FLIPR antibody; c-FLIPS antibody; CASP8 and FADD-like apoptosis regulator antibody
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Isotype
Rabbit IgG
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Preparation
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 161-480 of human CFLAR (NP_001120655.1).
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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Storage instructions
Store at -20℃. Avoid freeze / thaw cycles.
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Applications
WB 1:500 - 1:2000
IHC 1:50 - 1:200 -
Validations
Immunohistochemistry - CFLAR Polyclonal Antibody
Immunohistochemistry of paraffin-embedded human thyroid cancer using CFLAR antibody at dilution of 1:100 (40x lens).
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Background
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"