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Product Name
CEA antibody
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Description
CEA Rabbit Polyclonal antibody. Positive IHC detected in human colon cancer tissue, human colon tissue, human lung cancer tissue, human pancreas cancer tissue, human stomach cancer tissue.
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Tested applications
ELISA, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
Carcinoembryonic antigen antibody; CD66e antibody; CEA antibody; CEACAM5 antibody; DKFZp781M2392 antibody; Meconium antigen 100 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of CEA recombinant protein (Accession Number: NM_004363). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:109242(CEA antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human colon cancer using Catalog No:109242(CEA antibody) at dilution of 1:50 (under 40x lens)
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Background
Carcinoembryonic antigen (CEA), also known as CEACAM5 or CD66e, is a cell surface glycoprotein belonging to the immunoglobulin superfamily, mainly serving as a cell adhesion molecule mediating intercellular contact by both homophilic and heterophilic binding (PMID: 21731662). CEA inhibits anoikis and plays a role in tumorigenesis and metastasis. CEA has been found to be overexpressed in a wide variety of human cancers, including colon, breast, and lung (PMID: 17167768). CEA is a tumor marker and is routinely exploited for diagnosis.
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References
- Zhou PH, Zheng JB, Wei GB. Lentivirus-mediated RASSF1A expression suppresses aggressive phenotypes of gastric cancer cells in vitro and in vivo. Gene therapy. 22(10):793-801. 2015.
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