CDC34 antibody

CDC34 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CDC34 Rabbit Polyclonal antibody. Positive IP detected in mouse testis tissue. Positive WB detected in human pancreas tissue, human brain tissue. Positive IHC detected in human prostate cancer tissue. Observed molecular weight by Western-blot: 34 kDa

ELISA, WB, IHC, IP

Human,Mouse,Rat; other species not tested.

CDC34 antibody; E2 CDC34 antibody; UBC3 antibody; UBCH3 antibody; UBE2R1 antibody; Ubiquitin protein ligase R1 antibody

Rabbit IgG

This antibody was obtained by immunization of CDC34 recombinant protein (Accession Number: NM_004359). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

CDC34 is also named as UBCH3, UBE2R1(Ubiquitin-conjugating enzyme E2 R1) and belongs to the ubiquitin-conjugating enzyme family. Cdc34 enzyme is itself a substrate for the type of polyubiquitin modification that is known to cause targeting of proteins for degradation. It is phosphorylated in vivo, providing yet another potential means for control of its activity. And the predominantly nuclear localization of this enzyme suggests that substrate molecules relevant to its cell cycle function are similarly located within the nucleus(PMID:8164658). Human CDC34 could substitute efficiently for yeast CDC34(PMID:8248134). It can form a homodimer(PMID:8383676).

• Fiesel FC, Moussaud-Lamodière EL, Ando M, Springer W. A specific subset of E2 ubiquitin-conjugating enzymes regulate Parkin activation and mitophagy differently. Journal of cell science. 127(Pt 16):3488-504. 2014.