CD41/Integrin alpha 2b antibody

CD41/Integrin alpha 2b antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CD41/Integrin alpha 2b Mouse Monoclonal antibody. Positive WB detected in human spleen tissue. Observed molecular weight by Western-blot: 125 kDa

ELISA, WB

Human; other species not tested.

CD41 antibody; CD41/Integrin alpha 2b antibody; CD41B antibody; GP2B antibody; GPalpha IIb antibody; GPIIb antibody; GTA antibody; HPA3 antibody; Integrin alpha IIb antibody; ITGA2B antibody; ITGAB antibody

Mouse IgG1

This antibody was obtained by immunization of Peptide (Accession Number: NM_000419). Purification method: Protein G purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

CD41, also named as ITGA2B CD41B GPIIb GTA and HPA3, is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands and the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. CD41 is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. CD41 chain interacts with the ITGB3 (CD61) to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation.