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Product Name
CD38 antibody
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Description
CD38 Mouse Monoclonal antibody. Positive IF detected in NIH/3T3 cells. Positive WB detected in Jurkat cells, Raji cells. Observed molecular weight by Western-blot: 45 kDa
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Tested applications
ELISA, IF, WB
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
ADP ribosyl cyclase 1 antibody; cADPr hydrolase 1 antibody; CD38 antibody; CD38 molecule antibody; Cyclic ADP ribose hydrolase 1 antibody; T10 antibody
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Isotype
Mouse IgG1
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Preparation
This antibody was obtained by immunization of CD38 recombinant protein (Accession Number: NM_001775). Purification method: Caprylic acid/ammonium sulfate precipitation.
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Clonality
Monoclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IF: 1:10-1:100
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Validations
Jurkat cells were subjected to SDS PAGE followed by western blot with Catalog No:107133(CD38 Antibody) at dilution of 1:1000
Immunofluorescent analysis of NIH/3T3 cells using Catalog No:107133(CD38 Antibody) at dilution of 1:25 and Rhodamine-Goat anti-Mouse IgG
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Background
CD38 is also named as ADP-ribosyl cyclase 1 and belongs to the ADP-ribosyl cyclase family. The CD38 cDNA sequence predicts an unusual 30 kDa polypeptide with a short N-terminal cyto- plasmic tail, and a carboxyl-terminal extracellular domain carrying the four potential N-linked glyco- sylation sites(PMID:2319135). It usually acts as a 45 kDa bifunctional ectoenzyme that catalyzes the synthesis of cyclic ADP-ribose (cADPR) from NAD1 and the hydrolysis of cADPR to ADP-ribose(PMID:8663150). It has 2 isoforms produced by alternative splicing.
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