CD206 antibody

CD206 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CD206 Mouse Monoclonal antibody. Positive WB detected in human liver tissue, human placenta tissue. Observed molecular weight by Western-blot: 170 kDa

ELISA, WB

Human; other species not tested.

CD206 antibody; CLEC13D antibody; Macrophage mannose receptor 1 antibody; Mannose receptor antibody; mannose receptor antibody; C type 1 antibody; MMR antibody; MRC1 antibody

Mouse IgG2a

This antibody was obtained by immunization of Recombinant Protein (Accession Number: NM_002438). Purification method: Caprylic acid/ammonium sulfate precipitation.

Monoclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia. This antibody recognizes the intracellular carboxy-terminal part of CD206 and MRC1L1.

• Cui Z, Han D, Sun X. Mannose-modified chitosan microspheres enhance OprF-OprI-mediated protection of mice against Pseudomonas aeruginosa infection via induction of mucosal immunity. Applied microbiology and biotechnology. 99(2):667-80. 2015.