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Product Name
CD138/Syndecan-1 antibody
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Description
CD138/Syndecan-1 Rabbit Polyclonal antibody. Positive WB detected in Raji cells, HeLa cells. Positive IHC detected in human ovary tumor tissue. Observed molecular weight by Western-blot: 60-100 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
CD138 antibody; SDC antibody; SDC1 antibody; SYND1 antibody; syndecan antibody; syndecan 1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of CD138/Syndecan-1 recombinant protein (Accession Number: NM_002997). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
Raji cells were subjected to SDS PAGE followed by western blot with Catalog No:109052(SDC1,CD138 antibody) at dilution of 1:600
Immunohistochemical of paraffin-embedded human ovary tumor using Catalog No:109052(SDC1,CD138 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human ovary tumor using Catalog No:109052(SDC1,CD138 antibody) at dilution of 1:100 (under 40x lens)
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Background
Syndecan-1 (SDC1), also named CD138, is an integral membrane protein. It participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. It is a heparan sulfate proteoglycan expressed on the surface of, and actively shed by, myeloma cells. Altered syndecan-1 expression has been detected in several different tumor types. SDC1 was regarded as a useful marker for labeling normal and neoplastic plasma cells and plasmacytoid lymphomas.
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References
- Ding W, Ju S, Jiang S, Zhu L, Wang Y, Wang H. Reduced APRIL expression induces cellular senescence via a HSPG-dependent pathway. Pathology oncology research : POR. 15(4):693-701. 2009.
- Wang X, Zuo D, Chen Y. Shed Syndecan-1 is involved in chemotherapy resistance via the EGFR pathway in colorectal cancer. British journal of cancer. 111(10):1965-76. 2014.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"