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Product Name
CD11B/Integrin alpha M antibody
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Description
CD11B/Integrin alpha M Rabbit Polyclonal antibody. Positive IHC detected in human tonsillitis tissue, human spleen tissue.
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Tested applications
ELISA, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
CD11B antibody; CR 3 alpha chain antibody; CR3A antibody; Integrin alpha M antibody; ITGAM antibody; MAC 1 antibody; MAC1A antibody; MO1A antibody; Neutrophil adherence receptor antibody; SLEB6 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of CD11B/Integrin alpha M recombinant protein (Accession Number: NM_000632). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
IHC: 1:20-1:200
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Validations
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:109042(CD11B Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using Catalog No:109042(CD11B Antibody) at dilution of 1:50 (under 40x lens)
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Background
ITGAM, also named as CD11B and CR3A, belongs to the integrin alpha chain family. It is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. ITGAM is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. It is also a receptor for fibrinogen, factor X and ICAM1. ITGAM recognizes P1 and P2 peptides of fibrinogen gamma chain.
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