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Product Name
CC2D2A antibody
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Description
CC2D2A Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells. Positive IHC detected in human lung cancer tissue. Positive IF detected in hTERT-RPE1 cells. Observed molecular weight by Western-blot: 190 kDa
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Tested applications
ELISA, WB, IF, IHC
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
CC2D2A antibody; JBTS9 antibody; KIAA1345 antibody; MKS6 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_020785). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
IF: 1:20-1:200
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Validations
HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:108953(CC2D2A antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human lung cancer slide using Catalog No:108953(CC2D2A Antibody) at dilution of 1:50(under 10x lens)
Immunohistochemistry of paraffin-embedded human lung cancer slide using Catalog No:108953(CC2D2A Antibody) at dilution of 1:50(under 40x lens)
IF result (strong nucleus and the base stain) of anti-CC2D2A (Catalog No:108953, 1:50) with serum-starved hTERT-RPE1 (MeOH fixed) by Dr. Moshe Kim.
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Background
CC2D2A, also named as KIAA1345, may be involved in cilia formation. CC2D2A encodes a protein with similar overall structure to RPGRIP1L, including coiled-coil domains, a C2 domain, and an overlapping centrosomal protein-related domain. CC2D2A physically interacts with CEP290, and loss of Cc2d2a function in the zebrafish sentinel mutant results in abnormal body shape and pronephric (kidney) cysts that is strongly exacerbated by knockdown of Cep290 function. (PMID:19778711 )Defects in CC2D2A are the cause of Meckel syndrome type 6 (MKS6). Defects in CC2D2A are the cause of Joubert syndrome type 9 (JBTS9). The antibody is specific to CC2D2A.
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