CC2D1A antibody

CC2D1A antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CC2D1A Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive IHC detected in human testis tissue, human brain tissue, human liver tissue, human skin tissue. Positive IP detected in mouse liver tissue. Positive WB detected in HEK-293 cells, HeLa cells, Jurkat cells, mouse liver tissue. Observed molecular weight by Western-blot: 130 kDa, 104 kDa

ELISA, WB, IHC, IF, IP

Human,Mouse,Rat; other species not tested.

CC2D1A antibody; FREUD 1 antibody; Freud 1/Aki1 antibody; MRT3 antibody

Rabbit IgG

This antibody was obtained by immunization of CC2D1A recombinant protein (Accession Number: NM_017721). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

CC2D1A (coiled-coil and C2 domain-containing 1A), also known as Freud-1, Aki1 or TAPE (TBK1-associated protein in endolysosomes), is a evolutionary conserved protein located in different subcellular compartments, including the nucleus, centrosome, and endolysosomes. It acts as a scaffold protein that interacts with various proteins and plays diverse biological roles. Mutations in CC2D1A have been linked to nonsyndromic mental retardation(NMSR) and generate a truncated 85-kDa product. Several isoforms of CC2D1A proteins have also been described: 120 /130-kDa doublet of long isoform and 67 kDa short isoform. The short isoform of CC2D1A has been identified as the predominant isoform in rodent cells, while the long isoform is more abundant in human cells. Recently it has been reported that CC2D1A/TAPE is the first innate immune regulator implicated in both TLR and RLR signaling at a very early step.

• Chen KR, Chang CH, Huang CY. TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity. The Journal of biological chemistry. 287(38):32216-21. 2012.