CBX5 antibody

CBX5 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

CBX5 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, A431 cells, HEK-293 cells, human kidney tissue, K-562 cells, MCF7 cells, MCF-7 cells. Positive IP detected in HEK-293 cells. Observed molecular weight by Western-blot: 25-30 kDa

ELISA, WB, IP

Human,Mouse,Rat; other species not tested.

Antigen p25 antibody; CBX5 antibody; Chromobox protein homolog 5 antibody; HP1 antibody; HP1 alpha antibody; HP1A antibody

Rabbit IgG

This antibody was obtained by immunization of CBX5 recombinant protein (Accession Number: NM_001127321). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Chromobox protein homolog 5 (CBX5), also named heterochromatin protein 1 alpha (HP1a), is a highly conserved nonhistone protein involved in heterochromatin formation and gene silencing in different species including humans.HP1a is a Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). It may interact with lamin-Breceptor. HP1a is involved in the formation of functional kinetochore through interaction with MIS12complex proteins. Phosphorylation of HP1 and LBR during interphase mitosis may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle.The HP1a was expressed in nucleus and associates specifically with chromatin during metaphase and anaphase.Recent studies have shown that HP1a is present at many euchromatic sites and positively regulates euchromatic gene expression through RNA transcript association and interaction with hnRNPs in Drosophila (19798443). This antibody is a rabbit polyclonal antibody raised against a full-length human HP1A protein ,and can reacts with the 28kd HP1A protein.