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Product Name
Caveolin-1 antibody
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Description
Caveolin-1 Mouse Monoclonal antibody. Positive IHC detected in human lung cancer tissue, human heart tissue. Positive WB detected in PC-3 cells. Observed molecular weight by Western-blot: 22kD
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Isotype
Mouse IgG1
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Preparation
This antibody was obtained by immunization of Caveolin-1 recombinant protein (Accession Number: BC006432). Purification method: Protein G purified.
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Clonality
Monoclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:107035(CAV1 antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:107035(CAV1 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:107035(CAV1 antibody) at dilution of 1:50 (under 40x lens)
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Background
Caveolin-1 (CAV1), a multifunctional protein, is the main constituent molecule of caveolae and represents a scaffolding molecule for several signaling molecules including epidermal growth factor receptor (PMID: 19641024). Several studies have implicated that a reduced expression of CAV1 was found in cancers including head and neck carcinoma (PMID: 19002186). However, other studies recognize CAV1 as a tumor promoter because CAV1 is overexpressed in various kinds of cancers, especially in oral cancer (PMID: 20558341). Recent study also show that CAV1 is involved in astric Cancer (PMID: 25339030). Catalog#16447-1-AP is a rabbit polyclonal antibody raised against the full-length of human CAV1.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"