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CARD9 antibody

Cat.#: 108858

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Special Price 239.0 USD

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Product Information

  • Product Name
    CARD9 antibody
  • Documents
  • Description
    CARD9 Rabbit Polyclonal antibody. Positive WB detected in PC-3 cells, HEK-293 cells, HL-60 cells, human placenta tissue. Observed molecular weight by Western-blot: 50-59kd
  • Tested applications
    ELISA, WB
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    CARD9 antibody; hCARD9 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of CARD9 recombinant protein (Accession Number: NM_052814). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

  • Validations

    PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:108858(CARD9 antibody) at dilution of 1:500

    PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:108858(CARD9 antibody) at dilution of 1:500

    HL-60 cells were subjected to SDS PAGE followed by western blot with Catalog No:108858(CARD9 antibody) at dilution of 1:300

    HL-60 cells were subjected to SDS PAGE followed by western blot with Catalog No:108858(CARD9 antibody) at dilution of 1:300

  • Background
    CARD9, a member of the caspase recruitment domain (CARD) protein family, plays an important regulatory role in cell apoptosis. Defects in CARD9 are the cause of familial candidiasis type 2 (CANDF2) characterized by impaired clearance of fungal infections and results in colonization and infections of the mucosa or skin, predominantly with Candida albicans. CARD9 is highly expressed in spleen and regulate activation of NF-kappa-B by interaction with postive regulator of apoptosis BCL10 via the CARD domain.
  • References
    • Drewniak A, Gazendam RP, Tool AT. Invasive fungal infection and impaired neutrophil killing in human CARD9 deficiency. Blood. 121(13):2385-92. 2013.
    • Herbst M, Gazendam R, Reimnitz D. Chronic Candida albicans Meningitis in a 4-Year-Old Girl with a Homozygous Mutation in the CARD9 Gene (Q295X). The Pediatric infectious disease journal. 34(9):999-1002. 2015.
    • Drummond RA, Collar AL, Swamydas M. CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System. PLoS pathogens. 11(12):e1005293. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"