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Product Name
Carboxypeptidase M antibody
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Description
Carboxypeptidase M Rabbit Polyclonal antibody. Positive WB detected in HEK-293 cells. Observed molecular weight by Western-blot: 54 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human; other species not tested.
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Alternative names
Carboxypeptidase M antibody; CPM antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Carboxypeptidase M recombinant protein (Accession Number: NM_198320). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
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Validations
HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:108853(CPM antibody) at dilution of 1:600
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Background
CPM(Carboxypeptidase M), a plasma membrane-bound enzyme, is present in many human organs and differs from other carboxypeptidases that cleave basic C-terminal amino acids(PMID:2394713). CPM is structurally, catalytically and immunologically distinct from other carboxypeptidases, and expressed on cell membranes in a glycosyl-phosphatidylinositol-anchored form and it can be a novel marker and cellular player in lipid uptake and/or metabolism of MAs by promoting foam cell formation (PMID:22157720). This full length protein has a signal peptide with 17 amino acid, a propeptide with 20 amino acid and five glycosylation sites.
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