Calcium Sensing Receptor antibody

Calcium Sensing Receptor antibody

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Calcium Sensing Receptor Rabbit Polyclonal antibody. Positive IF detected in Hela cells. Positive WB detected in HL-60 cells, Jurkat cells. Observed molecular weight by Western-blot: 60-65 kDa

ELISA, WB, IF

Human,Mouse,Rat; other species not tested.

Calcium Sensing Receptor antibody; CAR antibody; CASR antibody; FHH antibody; FIH antibody; GPRC2A antibody; HHC antibody; HHC1 antibody; NSHPT antibody; PCAR1 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: NM_000388). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

CASR, also named as GPRC2A, PCAR1, belongs to the G-protein coupled receptor 3 family. Changes in extracellular calcium are thought to modulate a balance between proliferation and differentiation in a variety of cell types. The activity of CASR is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. It has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. In normal primary keratinocytes and breast epithelial cells, proliferation is inhibited and elevated extracellular calcium levels trigger differentiation. Malignant transformations of these cell types are accompanied by a loss of responsiveness to the anti-proliferative effects of elevated extracellular calcium. Several disorders of calcium homeostasis have been linked to mutations in the CaSR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo). The 60-65 kDa band detected by this antibody might represent a degradation product of CASR (PMID: 15718278).