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Product Name
C6 antibody
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Description
C6 Rabbit Polyclonal antibody. Positive IP detected in human plasma tissue. Positive WB detected in human blood tissue. Positive IHC detected in human liver cancer tissue. Observed molecular weight by Western-blot: 105 kDa
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
complement component 6 antibody; Complement component C6 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of C6 recombinant protein (Accession Number: NM_001115131). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:200-1:2000
IHC: 1:20-1:200
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Validations
human blood tissue were subjected to SDS PAGE followed by western blot with Catalog No:108739(C6 Antibody) at dilution of 1:1000
IP Result of anti-C6 (IP:Catalog No:108739, 4ug; Detection:Catalog No:108739 1:800) with human plasma tissue lysate 4000ug.
Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using Catalog No:108739(C6 Antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using Catalog No:108739(C6 Antibody) at dilution of 1:50 (under 40x lens)
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Background
The final consequence of complement activation is formation of the membrane attack complex (MAC), a multiprotein assembly that perforates cell membranes, forming transmembrane channels. C6 is 1 of 5 late-acting proteins of complement that participate in assembly and function of the MAC. The deduced C6 protein contains 934 amino acids, including a 21-amino acid N-terminal signal sequence and 2 N-glycosylation sites. Mutations in the C6 gene are associated with complement component-6 deficiency.
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