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c-Myc antibody

Cat.#: 109419

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Special Price 239.0 USD

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Product Information

  • Product Name
    c-Myc antibody
  • Documents
  • Description
    c-Myc Rabbit Polyclonal antibody. Positive WB detected in Raji cells, HeLa cells, NCCIT cell. Observed molecular weight by Western-blot: 62-65 kDa,50 kDa
  • Tested applications
    ELISA, WB
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    bHLHe39 antibody; c Myc antibody; c-Myc antibody; MRTL antibody; MYC antibody; Myc proto oncogene protein antibody; Proto oncogene c Myc antibody; Transcription factor p64 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Recombinant Protein (Accession Number: NM_002467). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

  • Validations

    Raji cells were subjected to SDS PAGE followed by western blot with Catalog No:109419(MYC antibody) at dilution of 1:800

    Raji cells were subjected to SDS PAGE followed by western blot with Catalog No:109419(MYC antibody) at dilution of 1:800

  • Background
    MYC contains one basic helix-loop-helix (bHLH) domain. This protein is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. It seems to activate the transcription of growth-related genes. It binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. This antibody is a rabbit polyclonal antibody raised against recombinant protein of human MYC.The 50kDa band recognized by antibody is the native form of MYC, while the other bands, between 60-70kDa, are the phosphorylated form of MYC [PMID: 12189186]
  • References
    • Xu B, Niu X, Zhang X. miR-143 decreases prostate cancer cells proliferation and migration and enhances their sensitivity to docetaxel through suppression of KRAS. Molecular and cellular biochemistry. 350(1-2):207-13. 2011.
    • Hong Y, Zhou Y, Wang Y, Xiao S, Liao DJ, Zhao Q. PPARγ mediates the effects of WIN55,212-2, an synthetic cannabinoid, on the proliferation and apoptosis of the BEL-7402 hepatocarcinoma cells. Molecular biology reports. 40(11):6287-93. 2013.
    • Chen XM, Bai Y, Zhong YJ. Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7α and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549. PloS one. 8(11):e79201. 2013.
    • Tang J, Tao ZH, Wen D. MiR-612 suppresses the stemness of liver cancer via Wnt/β-catenin signaling. Biochemical and biophysical research communications. 447(1):210-5. 2014.
    • Yang T, Zhang X, Wang M. Activation of mesenchymal stem cells by macrophages prompts human gastric cancer growth through NF-κB pathway. PloS one. 9(5):e97569. 2014.
    • Cui R, Zhang H, Guo X, Cui Q, Wang J, Dai J. Proteomic analysis of cell proliferation in a human hepatic cell line (HL-7702) induced by perfluorooctane sulfonate using iTRAQ. Journal of hazardous materials. 299:361-70. 2015.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"