Human CCL8/MCP-2 (His Tag) recombinant protein

Cat.#: 502504

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Product Information

  • Product Name
    Human CCL8/MCP-2 (His Tag) recombinant protein
  • Documents
  • Description
    Chemokines are a family of small chemotactic cytokines, or proteins secreted by cells. Chemokines share the same structure similarities such as small size, and the presence of four cysteine residues in conserved locations in order to form their 3-dimensional shape. Some of the chemokines are considered pro-inflammatory which can be induced to recruit cells of the immune system to a site of infection during an immune response, while others are considered homeostatic and are implied in controlling the migration of cells during normal processes of tissue maintenance and development. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands-1 to 28. Chemokine ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP-2), is a small cytokine belonging to the C-C chemokine family. CCL8 functions to activate different immune cells, including mast cells, eosinophils and basophils which are involved in allergic responses, monocytes, and T cells and NK cells which are involved in the inflammatory response. CCL8's ability achieves by binding to different cell surface receptors termed chemokine receptors including CCR1, CCR2B and CCR5. It has been reported that CCL8 is a potent inhibitor of HIV-1 by virtue of its binding to CCR5 which is one of the major co-receptors for HIV-1.
  • Protein name
    C-C motif chemokine 8
  • Protein short names
    SCYA8; SCYA10; MCP-2; CCL8; AB023418; HC14; RP23-446K18.1; MCP2; 1810063B20RIK
  • Uniprot ID
    P80075
  • Gene Name
    CCL8; MCP2; SCYA10; SCYA8
  • Source/Expression Host
    Yeast
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human CCL8 (NP_005614.2) (Gln24-Pro99) was expressed with a polyhistidine tag at the C-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human CCL8 consists of 86 amino acids and predicts a molecular mass of 10.3 kDa.
  • Purity
    > 95 % as determined by SDS-PAGE.
  • Validations

    Human CCL8 / MCP-2 Protein (His Tag)

    Human CCL8 / MCP-2 Protein (His Tag)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"