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Product Name
Human CCL4 / MIP1B (His Tag) recombinant protein
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Description
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
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Protein name
C-C motif chemokine 4
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Protein short names
SIS-GAMMA; ACT2; G-26 T-LYMPHOCYTE-SECRETED PROTEIN; RP23-320E6.8; CHEMOKINE (C-C MOTIF) LIGAND 4; IMMUNE ACTIVATION PROTEIN 2; MIP-1 BETA; ACT-2; T-CELL ACTIVATION PROTEIN 2; G-26; CCL4; SMALL INDUCIBLE CYTOKINE A4; C-C MOTIF CHEMOKINE 4; AT744.1; MIP-1B; PAT 744; HC21; SMALL INDUCIBLE CYTOKINE A4 (HOMOLOGOUS TO MOUSE MIP-1B); SCYA2; MIP-1-BETA; LYMPHOCYTE ACTIVATION GENE 1 PROTEIN; LAG-1; MACROPHAGE INFLAMMATORY PROTEIN 1-BETA; MIP1B; MIP1B1; SCYA4; SECRETED PROTEIN G-26; MIP-1-BETA(1-69); LAG1; AT744.1
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Uniprot ID
P13236
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Gene Name
CCL4; LAG1; MIP1B; SCYA4
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Source/Expression Host
Yeast
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Expression Plasmid/cDNA
A DNA sequence encoding human CCL4 (NP_002975.1) (Ala24-Gln92) was expressed with a polyhistidine tag at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human CCL4 consists of 79 amino acids and predicts a molecular mass of 9.2 KDa. It migrates as an approximately 12-16 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human CCL4 / MIP1B Protein (His Tag) SDS-PAGE
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