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BRSK2 antibody

Cat.#: 108598

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Product Information

  • Product Name
    BRSK2 antibody
  • Documents
  • Description
    BRSK2 Rabbit Polyclonal antibody. Positive WB detected in mouse brain tissue, mouse testis tissue. Positive IHC detected in human prostate cancer tissue. Observed molecular weight by Western-blot: 80-88kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    BR serine/threonine kinase 2 antibody; BRSK2 antibody; C11orf7 antibody; FLJ41362 antibody; PEN11B antibody; SAD1 antibody; STK29 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of BRSK2 recombinant protein (Accession Number: BC024291). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:117245(BRSK2 antibody) at dilution of 1:500

    mouse brain tissue were subjected to SDS PAGE followed by western blot with Catalog No:117245(BRSK2 antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:117245(BRSK2 antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human prostate cancer using Catalog No:117245(BRSK2 antibody) at dilution of 1:50 (under 10x lens)

  • Background
    BRSK2 is highly conserved from invertebrates to human, plays a key role in polarization of neurons and has been identified with different names: SAD1 is its closest homolog in C. elegans, serine/threonine kinase SADA alfa in rat, brain-selective kinase 2 and SAD-B in mouse and hsSAD1 and SAD1B in humans(PMID:16165222) . In rat and mouse, BRSK2 is only detected in the brain and at low levels in the testis .It has 5 isoforms produced by alternative splicing.This protein has a conserved function throughout the evolution.
  • References
    • Morita T, Sobue K. Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway. The Journal of biological chemistry. 284(40):27734-45. 2009.
    • Yoshida H, Goedert M. Phosphorylation of microtubule-associated protein tau by AMPK-related kinases. Journal of neurochemistry. 120(1):165-76. 2012.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"