Cart 2

BRE antibody

Cat.#: 108585

Size:

Special Price 239.0 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    BRE antibody
  • Documents
  • Description
    BRE Rabbit Polyclonal antibody. Positive IP detected in PC-3 cells. Positive WB detected in PC-3 cells. Positive IHC detected in human gliomas tissue. Observed molecular weight by Western-blot: 44 kDa
  • Tested applications
    ELISA, WB, IHC, IP
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    BRCA1 A complex subunit BRE antibody; BRCC4 antibody; BRCC45 antibody; BRE antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of BRE recombinant protein (Accession Number: NM_199194). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:200-1:2000

    IHC: 1:20-1:200

  • Validations

    PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:117232(BRE antibody) at dilution of 1:500

    PC-3 cells were subjected to SDS PAGE followed by western blot with Catalog No:117232(BRE antibody) at dilution of 1:500

    Immunohistochemical of paraffin-embedded human gliomas using Catalog No:117232(BRE antibody) at dilution of 1:50 (under 10x lens)

    Immunohistochemical of paraffin-embedded human gliomas using Catalog No:117232(BRE antibody) at dilution of 1:50 (under 10x lens)

    IP Result of anti-BRE (IP:Catalog No:117232, 4ug; Detection:Catalog No:117232 1:500) with PC-3 cells lysate 2400ug.

    IP Result of anti-BRE (IP:Catalog No:117232, 4ug; Detection:Catalog No:117232 1:500) with PC-3 cells lysate 2400ug.

  • Background
    BRE, also named as BRCC45, is a death receptor-associated antiapoptotic protein, which is also involved in DNA-damage repair, and K63-specific deubiquitination. BRE and its XIAP-sustaining mechanism could represent novel targets for anti-cancer therapy. BRE may regulate TNF-alpha signaling through its interactions with TNFRSF1A. It plays a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. BRE gene has four isoforms with MW 42-47 kDa.
  • References
    • Wang B, Hurov K, Hofmann K, Elledge SJ. NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control. Genes & development. 23(6):729-39. 2009.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"