Biotin OPTN antibody

Biotin OPTN antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Biotin OPTN Mouse Monoclonal antibody. Positive WB detected in human brain. Observed molecular weight by Western-blot: 70-74 kDa

ELISA, WB

Human; other species not tested.

FIP 2 antibody; optineurin antibody; OPTN antibody

Mouse IgG1

This antibody was obtained by immunization of OPTN recombinant protein (Accession Number: NM_001008212). Purification method: Protein G purified.

Monoclonal

PBS(10mM), with 50% glycerol, without sodium azide.

Store at -20℃. DO NOT ALIQUOT

OPTN, also named as FIP2, GLC1E, HIP7, HYPL and NRP, plays a neuroprotective role in the eye and optic nerve. It is probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. OPTN may act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). OPTN may constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death. Defects in OPTN are the cause of primary open angle glaucoma type 1E (GLC1E). Defects in OPTN are a cause of susceptibility to normal pressure glaucoma (NPG). OPTN mutated in adult-onset primary open angle glaucoma. It supports the protective role of OPTN in the trabecular meshwork. This antibody is conjugated with Biotin.