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Product Name
Human COASY / CoA synthase (His Tag) recombinant protein
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Description
Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.
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Protein name
Bifunctional coenzyme A synthase
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Protein short names
BIFUNCTIONAL PHOSPHOPANTETHEINE ADENYLYL TRANSFERASE/DEPHOSPHO COA KINASE; COA SYNTHASE; PSEC0106; BIFUNCTIONAL COENZYME A SYNTHASE; COENZYME A SYNTHASE; NBIA6; POV-2; 1300003G02RIK; 4'-PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE AND DEPHOSPHO-COA KINASE; PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE / DEPHOSPHOCOENZYME A KINASE; PPAT; RP23-440M18.3; DPCK; COASY; UKR1; NBP; NUCLEOTIDE BINDING PROTEIN
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Uniprot ID
Q13057
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Gene Name
COASY; PSEC0106
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human COASY (Q13057-1) (Met296-Asp564) was expressed with a polyhistidine tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human COASY consists of 287 amino acids and predicts a molecular mass of 32.5 KDa. It migrates as an approximately 33 KDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human COASY / CoA synthase Protein (His Tag) SDS-PAGE
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