BHLHE41 Polyclonal Antibody

Cat.#: 166024

Special Price 290.3 USD

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Product Information

  • Product Name
    BHLHE41 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to BHLHE41
  • Tested applications
    WB, IF, FC
  • Species reactivity
    Human
  • Alternative names
    BHLHE41 antibody; BHLHB3 antibody; DEC2 antibody; SHARP1 antibody; hDEC2 antibody; basic helix-loop-helix family member e41 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic Peptide of human BHLHE41
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, pH7.3.
  • Storage instructions
    Store at 4℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:1000
    IF 1:20 - 1:50
    FC 1:20 - 1:50
  • Validations

    Western blot - BHLHE41 Polyclonal Antibody

    Western blot - BHLHE41 Polyclonal Antibody

    Western blot analysis of extracts of human brain, using BHLHE41 antibody .Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.

  • Background
    Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"